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In search of developing more effective pain drugs, scientists study how CBD inhibits pain

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In recent years, cannabidiol, a compound derived from cannabis plants, has begun to appear more and more in everyday life. Now legal in most USA.
#Onquest #developeffective #painmedicines #scientists
Harvard Medical School

In recent years, cannabidiol, a compound derived from cannabis plants, has begun to appear more and more in everyday life. Now legal in most US states for its pain suppression properties. But the CBD really relieves pain? If so, how precisely do you? And what would be needed to take advantage of the beneficial properties of the CBD in a safe and effective pain medication? These are some of the questions Bruce Bean, the professor of Neurobiology at Robert Winthrop at the Blavatnik Institute at Harvard’s Faculty of Medicine, and Clifford Woolf, professor of Neurology at HMS at the Boston Children’s Hospital, have joined to explore. His research so far, carried out in animal models and cells, suggests that the CBD acts simultaneously on two objectives in pain detection neurons. They are now using this information to develop medications that work in the same way as the CBD and are equally safe and non -addictive, but the body absorbs the body more effectively. Uncreated pain is a significant and generalized health problem that can interfere with daily activities, lead to poor mental health and, in general, result in a reduced quality of life for those affected. The centers for the control and prevention of diseases of the US . A previous study suggests that the economic cost of chronic pain in the United States is between $ 560 and $ 635 billion per year. However, some of the pain medications currently available and commonly prescribed have enormous addictive potential, leaving those who use them vulnerable to being dependent. “Something that would relieve pain that is not addictive is a great unsatisfied need, and remains one of the most formidable challenges in modern medicine,” said Bean. A research convergence

Bean and Woolf have long shared the interest in developing better pain medications. Currently, effective pain treatments are somewhat limited, Woolf said, and pain -based medications prescribed for pain entail a significant risk of addiction, contributing in part to the widespread opioid crisis. In fact, the CDC estimates that since 1999, more than 932,000 people have an overdose of drugs, and in 2021, opioids were involved in 75.1 percent of overdose, claiming 80,816

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